Schulze G, Tetzner M, Topolinski H
Naunyn Schmiedebergs Arch Pharmacol. 1981 Dec;318(1):43-8. doi: 10.1007/BF00503311.
The relative importance of different effector mechanisms of thermoregulation may change depending on their availability. Intact rats make only limited use of a learned response on a cold ambient temperature stimulus, and rely almost entirely on autonomic regulatory functions. After destruction of the anterior hypothalamus, rats exhibit a reduced thermoregulatory capacity; i.e. body temperature drops in the cold and rises in the heat. Under this situation a conditioned operant behavior (lever pressing for increasing or decreasing ambient temperature) becomes an important factor to keep body temperature almost constant. Receptor blockers of some putative transmitters in central thermoregulatory pathways influence thermoregulation. Phentolamine induces hypothermia in intact rats in the cold. Hypothalamic lesions are additive in effect with with the drug. Pimozide has no effect neither in the cold nor in the heat intact and lesioned rats. Biperiden in the heat reinforces hyperthermia in intact and lesioned rats as well; in the cold the drug is ineffective. Performance of lesioned rats in an operant pain titration procedure does not differ from intact rats.
体温调节的不同效应机制的相对重要性可能会因其可用性而改变。完整的大鼠对寒冷环境温度刺激的习得反应利用有限，几乎完全依赖自主调节功能。在前下丘脑被破坏后，大鼠的体温调节能力降低；即体温在寒冷中下降，在炎热中上升。在这种情况下，一种条件性操作行为（按压杠杆以升高或降低环境温度）成为使体温几乎保持恒定的重要因素。中枢体温调节途径中一些假定递质的受体阻滞剂会影响体温调节。酚妥拉明在寒冷环境中会使完整大鼠体温过低。下丘脑损伤与该药物具有累加效应。匹莫齐特在完整和损伤大鼠中，无论在寒冷还是炎热环境中均无作用。比哌立登在炎热环境中也会增强完整和损伤大鼠的体温过高；在寒冷环境中该药物无效。损伤大鼠在操作性疼痛滴定程序中的表现与完整大鼠无异。
