Dunn J D, Johnson D C
Neuroendocrinology. 1978;27(3-4):126-35. doi: 10.1159/000122805.
To determine whether adrenocortical function influences rhythmic gonadotropin patterns in male rats, blood samples were obtained by rapid decapitation from control and adrenalectomized male rats at 3-h intervals over a 24-h period (14 h light/day, 4 a.m.--6 p.m.). Control animals showed periodicity in serum LH, prolactin (Prl) and corticosterone similar to that reported previously. Peak and trough serum levels of corticosterone and Prl occurred at 5 p.m. and 8 a.m. respectively whereas those for LH occurred at 11 p.m. and 11 a.m. Serum FSH levels did not vary with circadian periodicity. 15 days after adrenalectomy, serum LH levels continued to fluctuate with a circadian periodicity but showed a marked phase shift; peak LH levels were observed at 8 a.m. The absence of adrenal hormones did not result in altered FSH levels nor was the phase of the Prl rhythm significantly altered.
为了确定肾上腺皮质功能是否影响雄性大鼠促性腺激素的节律模式，在24小时内（14小时光照/天，上午4点至下午6点），每隔3小时通过快速断头法从对照雄性大鼠和肾上腺切除的雄性大鼠获取血样。对照动物血清促黄体生成素（LH）、催乳素（Prl）和皮质酮呈现出的周期性与先前报道的相似。皮质酮和Prl的血清峰值和谷值分别出现在下午5点和上午8点，而LH的峰值和谷值分别出现在晚上11点和上午11点。血清促卵泡生成素（FSH）水平不随昼夜节律变化。肾上腺切除术后15天，血清LH水平继续随昼夜节律波动，但出现明显的相位偏移；LH峰值出现在上午8点。肾上腺激素的缺失并未导致FSH水平改变，Prl节律的相位也未发生显著改变。
