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生命起源的一种理论。

A theory of the origin of life.

作者信息

Olson C B

出版信息

Orig Life. 1981 Dec;11(4):353-68. doi: 10.1007/BF00931490.

Abstract

Life on Earth is essentially nucleic acids (NAs) influencing peptide synthesis such that NA replication is favored. It is proposed that the ability to synthesize polypeptides evolved gradually - one peptide bond at a time. The proposed evolution of the peptide synthesis apparatus begins with a 'transfer NA' (tNA) which catalyzes the transfer of activated amino acids to accessible amino groups in its environment. The resulting 'capped molecules' (with single amino acid 'caps') in turn favor NA replication. The proposed evolution of the peptide synthesis apparatus from the tNA onward is characterized by a progressive increase in the number of amino acids per cap: two tNAs jointly produce a 'dipeptide cap', three tNAs jointly produce a 'tripeptide cap', etc. Messenger NAs evolve because they can specify the composition and sequence order of the peptide caps. Lastly, ribosomal NAs evolve. The origin, expansion, and standardization of the genetic code are discussed. It is proposed that the presence triplet code evolved by a process of codon length refinement, and the originally codons of varying lengths were allowable, as were unassigned bases between codons. An environmental supply of activated compounds for early evolving entities is proposed. An 'environmental retention and redistribution process' is proposed to have acted as a functional substitute for the cell wall and cell division of early evolving entities.

摘要

地球上的生命本质上是核酸(NAs)影响肽合成,从而有利于NA复制。有人提出,合成多肽的能力是逐渐进化的——一次形成一个肽键。肽合成装置的进化过程被认为始于一种“转移核酸”(tNA),它催化活化氨基酸转移到其周围环境中可及的氨基上。由此产生的“加帽分子”(带有单个氨基酸“帽”)反过来又有利于NA复制。从tNA开始的肽合成装置的进化过程的特点是每个帽上的氨基酸数量逐渐增加:两个tNA共同产生一个“二肽帽”,三个tNA共同产生一个“三肽帽”,等等。信使核酸的进化是因为它们可以指定肽帽的组成和序列顺序。最后,核糖体核酸进化。文中讨论了遗传密码的起源、扩展和标准化。有人提出,三联体密码的出现是通过密码子长度细化的过程进化而来的,最初不同长度的密码子是允许的,密码子之间未分配的碱基也是允许的。文中提出了早期进化实体的活化化合物的环境供应。有人提出,一种“环境保留和重新分配过程”起到了早期进化实体细胞壁和细胞分裂的功能替代作用。

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