脑室内注射海藻酸对大鼠大脑皮层和纹状体中乙酰胆碱含量及释放的影响。
The effects of intracerebroventricularly applied kainic acid on acetylcholine content and release in rat brain cortex and striatum.
作者信息
Kleinrok A, Tomaszewski A, Billewicz-Stankiewicz J
出版信息
Pol J Pharmacol Pharm. 1981 Nov;33(4):453-8.
PMID:7329869
Abstract
Kainic acid applied intracerebroventricularly at a dose of 0.1 micrograms/rat decreased the ACh level inthe cortex and increased it in the striatum 3 h after the injection. ACh release 3 h from the moment of injection was depressed in both examined structure. 1, 5 and 20 days after injection, ACh level and release were depressed in the striatum.
摘要
以0.1微克/大鼠的剂量脑室内注射海人酸，在注射后3小时可降低皮质中的乙酰胆碱水平，并增加纹状体中的乙酰胆碱水平。从注射时刻起3小时，在所检查的两个结构中乙酰胆碱释放均受到抑制。注射后1天、5天和20天，纹状体中的乙酰胆碱水平和释放均受到抑制。
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