正常受试者中四种缓释茶碱制剂的单剂量比较。
A single-dose comparison of four slow-release theophylline preparations in normal subjects.
作者信息
Sharma J N, Johnston A, Blackett A, Hathway N R
出版信息
Postgrad Med J. 1981 Mar;57(665):153-5. doi: 10.1136/pgmj.57.665.153.
The plasma theophylline concentrations produced by 4 different slow release formulations, Theograd, Theodur, Theolair-SR and Rona-slophylline were measured over a 24-hr period in 8 healthy subjects. All 4 preparations maintained plasma levels over 12 hr and had similar AUC values when the difference in theophylline content was taken into account. Paired saliva and plasma theophylline concentrations gave a ratio of 1: 0·38, saliva: plasma, but with a large inter and intra individual variation.
在8名健康受试者中，对4种不同缓释制剂（Theograd、Theodur、Theolair-SR和Rona-slophylline）在24小时内产生的血浆茶碱浓度进行了测量。当考虑到茶碱含量的差异时，所有4种制剂在12小时以上维持血浆水平，且具有相似的AUC值。配对的唾液和血浆茶碱浓度得出唾液与血浆的比例为1:0.38，但个体间和个体内存在较大差异。
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