Ford A M, Fagerberg D J, Quarles C L, George B A, McKinley G A
Poult Sci. 1981 Nov;60(11):2441-53. doi: 10.3382/ps.0602441.
Twenty broiler chickens were fed 80 g/T salinomycin, an antibiotic produced by Streptomyces albus, and 20 birds were fed a control, unmedicated feed. The birds were experimentally infected with Salmonella typhimurium. The study evaluated the effects of salinomycin on Salmonella incidence, shedding, and antimicrobial resistance. Salinomycin had no effect on body weights, length of time salmonellae were shed, number of salmonellae shed on postdosing day 3, salmonellae tissue recoverability, or on the total number of resistance patterns. Salinomycin caused the decline of salmonellae to be more gradual; however, both treatments were comparable at the end of the study. The majority of isolated from birds receiving salinomycin maintained the original S. typhimurium antibiogram of streptomycin, sulfadiazine, and nalidixic acid. The salinomycin salmonellae were more susceptible to tetracycline, amikacin, carbenicillin, gentamicin, and cephalothin. The multiple resistance patterns of eight and nine drugs tended to be more prevalent among salmonellae from control birds than salinomycin treated birds. The antibiotic salinomycin appears to be an acceptable feed additive in broilers at the level of 80 g/T based on these results of its effects on salmonellae shedding and antimicrobial resistance.
给20只肉鸡饲喂80克/吨的盐霉素（一种由白色链霉菌产生的抗生素），另外20只鸡饲喂对照未添加药物的饲料。这些鸡被实验性感染鼠伤寒沙门氏菌。该研究评估了盐霉素对沙门氏菌发病率、排菌情况及抗菌药物耐药性的影响。盐霉素对体重、沙门氏菌排菌时间、给药后第3天的排菌数量、沙门氏菌组织可恢复性或耐药模式总数均无影响。盐霉素使沙门氏菌数量下降更为缓慢；然而，在研究结束时两种处理相当。从接受盐霉素的鸡中分离出的大多数菌株保持了鼠伤寒沙门氏菌对链霉素、磺胺嘧啶和萘啶酸的原始抗菌谱。盐霉素处理的沙门氏菌对四环素、阿米卡星、羧苄青霉素、庆大霉素和头孢噻吩更敏感。对照鸡的沙门氏菌中，对8种和9种药物的多重耐药模式往往比盐霉素处理的鸡更为普遍。基于其对沙门氏菌排菌和抗菌药物耐药性的影响结果，抗生素盐霉素在80克/吨的水平似乎是肉鸡中一种可接受的饲料添加剂。
