George B A, Fagerberg D J, Quarles C L, Fenton J M, McKinley G A
Am J Vet Res. 1982 Feb;43(2):299-303.
Twenty broiler chickens were fed bambermycins (Flavomycin; an antibiotic produced by Streptomyces) at the rate of 3 g/ton (US) for 63 days, and 20 control birds were fed nonmedicated feed. The birds were inoculated (dosed) on the 10th and 11th feeding day with Salmonella typhimurium. The study evaluated the effects of bambermycins on Salmonella incidence, shedding, and antimicrobial resistance. Bambermycins had no effect on body weights, duration of shedding of salmonellae, number of salmonellae shed on postdosing day 3, tissue recoverability of salmonellae, and total number of resistance patterns. Bambermycins resulted in the decrease of salmonellae to be more gradual; however, both treatments were comparable at the end of the study. The majority of S typhimurium from bambermycins-treated birds maintained the original antibiogram of streptomycin, sulfadiazine, and nalidixic acid. The salmonellae isolated from the control birds were more resistant to 2 drugs (varying antibiograms). Bambermycins as a feed additive in broiler diets given at the dose level of 3 g/ton had no detrimental effects based on salmonellae shedding and antimicrobial resistance.
20只肉鸡以3克/吨（美国）的剂量投喂黄霉素（由链霉菌产生的一种抗生素），持续63天，另外20只对照鸡投喂不含药物的饲料。在第10天和第11天投喂时给这些鸡接种鼠伤寒沙门氏菌。该研究评估了黄霉素对沙门氏菌发病率、排菌情况及抗菌耐药性的影响。黄霉素对鸡的体重、沙门氏菌排菌持续时间、给药后第3天的沙门氏菌排菌数量、沙门氏菌的组织可恢复性以及耐药模式总数均无影响。黄霉素使沙门氏菌数量的减少更为缓慢；然而，在研究结束时两种处理方式的效果相当。来自投喂黄霉素鸡的大多数鼠伤寒沙门氏菌维持了对链霉素、磺胺嘧啶和萘啶酸的原始药敏谱。从对照鸡分离出的沙门氏菌对两种药物更具耐药性（药敏谱各异）。基于沙门氏菌排菌情况和抗菌耐药性，3克/吨剂量水平的黄霉素作为肉鸡日粮中的饲料添加剂没有不良影响。
