Del Bono N, Sconosciuto F, Del Bono L
Respiration. 1981;42(4):273-7. doi: 10.1159/000194442.
A bioassay with tiaramide hydrochloride (THC) and placebo was performed in 32 non-asthmatic patients suffering from chronic obstructive lung disease. Each patient received one administration of THC (200 mg) and one of placebo according to a double-blind cross-over design. FVC, FEV1, FM25-75, PEF and FEF200-1,200 were measured before and at several intervals until 360 min after treatment. Significant differences were found between drug and placebo which gave no significant variations. It is concluded that THC is an effective and safe bronchodilator. The substained bronchodilator effect shown by THC appears to be a clinical advantage.
对32名患有慢性阻塞性肺疾病的非哮喘患者进行了盐酸替拉米特（THC）和安慰剂的生物测定。根据双盲交叉设计，每位患者接受一次THC（200mg）给药和一次安慰剂给药。在治疗前及治疗后直至360分钟的几个时间间隔测量用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、用力呼气中期流量（FM25 - 75）、呼气峰值流速（PEF）和200 - 1200用力呼气流量（FEF200 - 1200）。发现药物与安慰剂之间存在显著差异，而安慰剂无显著变化。得出结论，THC是一种有效且安全的支气管扩张剂。THC所显示的持续支气管扩张作用似乎是一项临床优势。
