Hardin B D, Bond G P, Sikov M R, Andrew F D, Beliles R P, Niemeier R W
Scand J Work Environ Health. 1981;7 Suppl 4:66-75.
The reproductive toxicity and teratogenic potential of 19 industrial chemicals have been investigated during the past 3 a. Preliminary studies utilizing intraperitoneal treatments of rats on days 1-15 of gestation have been conducted on the following ten chemicals: allyl chloride, bisphenol A, copper naphthenate, ethylene dibromide, hexachlorobutadiene, 2-mercaptobenzothiazole, methyl styrene, naphthalene, 2-nitropropane, and 1,2,3-trichloropropane. Studies utilizing inhalation exposure of rats and rabbits on days 1-19 and 1-24, respectively, of gestation have been conducted on the following nine chemicals: butylene oxide, carbon disulfide, 2-ethoxyethanol, ethyl benzene, methyl bromide, nitrous oxide, styrene oxide, tetrachloroethylene, and trichloroethylene. In the preliminary studies, evidence of teratogenic potential was seen with allyl chloride and bisphenol A, and fetal toxicity was found in the absence of maternal toxicity with methyl styrene and 2-nitropropane. In the inhalation studies, 2-ethoxyethanol was strongly embryotoxic at the higher exposure levels employed and was teratogenic at the lower concentration.
在过去3年里，已对19种工业化学品的生殖毒性和致畸潜力进行了研究。已对以下10种化学品进行了初步研究，即在妊娠第1至15天对大鼠进行腹腔注射：烯丙基氯、双酚A、环烷酸铜、1,2-二溴乙烷、六氯丁二烯、2-巯基苯并噻唑、甲基苯乙烯、萘、2-硝基丙烷和1,2,3-三氯丙烷。已对以下9种化学品进行了研究，即在妊娠第1至19天对大鼠进行吸入暴露，在妊娠第1至24天对兔子进行吸入暴露：环氧丁烷、二硫化碳、2-乙氧基乙醇、乙苯、甲基溴、一氧化二氮、氧化苯乙烯、四氯乙烯和三氯乙烯。在初步研究中，烯丙基氯和双酚A有潜在致畸证据，甲基苯乙烯和2-硝基丙烷在无母体毒性的情况下发现有胎儿毒性。在吸入研究中，2-乙氧基乙醇在较高暴露水平时有强烈胚胎毒性，在较低浓度时有致畸性。
