氟烷麻醉后不明原因肝炎患者的 HLA A 和 B 位点抗原

HLA A and B locus antigens in patients with unexplained hepatitis following halothane anaesthesia.

作者信息

Eade O E, Grice D, Krawitt E L, Trowell J, Albertini R, Festenstein H, Wright R

出版信息

Tissue Antigens. 1981;17(4):428-32. doi: 10.1111/j.1399-0039.1981.tb00724.x.

DOI:10.1111/j.1399-0039.1981.tb00724.x

Abstract

HLA A and B locus antigens were determined in 17 patients who had recovered from unexplained hepatitis following halothane anaesthesia. The greatest deviations from expected frequencies were observed with A1, A11 and BW22, but these differences were not statistically significant when the P values were corrected for the number of antigens tested. Although a larger series might show such deviations to be significantly different, HLA typing is of no predictive value in determining those at risk to hepatitis following repeated halothane exposure.

摘要

对17例在氟烷麻醉后从不明原因肝炎中康复的患者进行了HLA A和B位点抗原检测。观察到与预期频率偏差最大的是A1、A11和BW22，但在对检测的抗原数量进行P值校正后，这些差异无统计学意义。尽管更大规模的系列研究可能会显示这种偏差有显著差异，但HLA分型在确定反复接触氟烷后有肝炎风险的人群方面没有预测价值。