Diminution of bile flow and of liver uptake and biliary excretion of bromsulphthalein by aldosterone.

In adult albino rabbits, aldosterone infusion in doses between 0.0217 and 11.00 micrograms/kg b.wt/min resulted in a rapid diminution of bile flow (p less than 0.01). The biliary excretion of sodium and water was decreased. The liver uptake, the biliary excretion and the choleretic response to cholic acid were diminished in animals infused with aldosterone. The intravenous injection of 15 mg/kg b. wt of bromsulphthalein, in rabbits infused with aldosterone produced a diminution of plasma clearance and biliary excretion of the dye (p less than 0.01).