Porias H, Carranco-López A, Sojo-Aranda I, González-Martínez R, Cervantes C, Parra A, Cortés-Gallegos V
Obstet Gynecol. 1978 Dec;52(6):703-7.
A total of 134 women were studied, 75 of whom were using cyclic steroid contraception (ethinyl estradiol, 0.05 mg plus norgestrel, 0.5 mg) and 59 of whom had normal ovaulatory cycles. By radioimmunoassay techniques simultaneous determinations were made of total estrogens (TE) and progesterone (P) in both plasma and endometrium and of FSH and LH in plasma, covering all days of the pseudomenstrual and true menstrual cycles. As expected, the ovulating women showed a midcycle peak of plasma TE and an increase in plasma P thereafter, while no cyclic variations were observed in the treated group. Correlations of endometrial concentrations of TE and P with plasma FSH and LH levels are discussed. In 13 of the 75 treated women elevations of endometrial P concentrations were present, presumably demonstrating the "escape phenomenon." The possible future value of endometrial hormone determinations is suggested.
共对134名女性进行了研究，其中75名使用周期性甾体避孕药（炔雌醇0.05毫克加炔诺孕酮0.5毫克），59名有正常排卵周期。通过放射免疫分析技术，同时测定了血浆和子宫内膜中的总雌激素（TE）和孕酮（P）以及血浆中的促卵泡激素（FSH）和促黄体生成素（LH），涵盖了假月经周期和真月经周期的所有天数。正如预期的那样，排卵女性血浆TE在周期中期出现峰值，此后血浆P升高，而治疗组未观察到周期性变化。讨论了子宫内膜中TE和P浓度与血浆FSH和LH水平的相关性。75名接受治疗的女性中有13名子宫内膜P浓度升高，推测显示出“突破现象”。提出了子宫内膜激素测定未来可能的价值。
