de Castro de Castro P, Pascual-Castroviejo I
An Esp Pediatr. 1981 Nov;15(5):443-8.
A study of mental development of 108 patients with craniosynostosis is performed. A serious mental retardation was evident in the majority of patients with "clover leaf" and in those with acrocephalosyndactily types Appert and Chotzen, and also when they had trigonocephaly. Oxicephaly, Crouzon's disease, plagiocephaly and Carpenter's and Pfeiffer's diseases show usually a moderate and/or middle retardation. Scaphocephaly has a mental evolution with a normal I.Q., but probability for presenting perinatal hipoxia because the size and aspect of the head is high.
对108例颅缝早闭患者的智力发育进行了研究。大多数“三叶草”型患者、阿佩尔型和乔岑型尖头并指（趾）畸形患者，以及三角头畸形患者均有明显的严重智力发育迟缓。长头畸形、克鲁宗病、斜头畸形、卡彭特病和法伊弗病通常表现为中度和/或中等程度的智力发育迟缓。舟状头畸形患者的智力发育正常，但由于头部大小和外形的原因，出现围产期缺氧的可能性较高。
