氯乙烯的致突变性研究。
Mutagenicity studies of vinyl chloride.
作者信息
Fabricant J D, Legator M S
出版信息
Environ Health Perspect. 1981 Oct;41:189-93. doi: 10.1289/ehp.8141189.
Abstract
Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
摘要
对人类和试验生物的致突变性研究清楚地表明氯乙烯具有阳性致突变活性。在使用涵盖真核生物和原核生物的多种体外程序进行的致突变性研究中，发现了阳性效应。对动物和人类进行的体内细胞遗传学研究表明，这种化学物质不仅会导致体细胞突变，还会产生生殖细胞效应。
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本文引用的文献
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Mutagenicity of vinyl chloride in the Ames test: possible artifacts related to experimental conditions.氯乙烯在艾姆斯试验中的致突变性：与实验条件相关的可能假象。
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Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxiran formation.作为代谢环氧乙烷形成的函数，氯乙烯的体外诱变性和潜在致癌性。
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Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.氯乙醛的致突变性，氯乙醛是1,2 - 二氯乙烷（二氯化乙烯）、氯乙醇（氯乙醇）、氯乙烯和环磷酰胺的一种可能代谢产物。
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Carcinogenic, mutagenic and teratogenic risks associated with vinyl chloride.与氯乙烯相关的致癌、致突变和致畸风险。
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High rate of chromosomal aberration in PVC workers.聚氯乙烯工人染色体畸变率高。
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Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals.职业接触氯乙烯单体及其他化学物质的男性的染色体损伤。
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The non-mutagenicity and -recombinogenicity of vinyl chloride in the absence of metabolic activation.
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