Fabricant J D, Legator M S
Environ Health Perspect. 1981 Oct;41:189-93. doi: 10.1289/ehp.8141189.
Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
对人类和试验生物的致突变性研究清楚地表明氯乙烯具有阳性致突变活性。在使用涵盖真核生物和原核生物的多种体外程序进行的致突变性研究中，发现了阳性效应。对动物和人类进行的体内细胞遗传学研究表明，这种化学物质不仅会导致体细胞突变，还会产生生殖细胞效应。
