Fleig I, Thiess A M
J Occup Med. 1978 Aug;20(8):557-61.
Chromosome analysis was undertaken on lymphocyte cultures taken from (1) six workers with estimated exposure to VC and four workers with monitored exposure to VC (employed in the BASF); (2) 20 workers showing symptoms of VC illness with unknown exposure and one angiosarcoma case, due to VC exposure (not employed in the BASF); and, (3) on bone marrow cells of Chinese hamsters after inhalation of 2,500 ppm or 5,000 ppm, or after intraperitoneal injections of 300 mg/kg or 600 mg/kg. The proband groups showing symptoms of VC illness, the only living angiosarcoma case, and the animal test show a significant increase in the rate of aberrations in comparison to the control group.
（1）6名估计接触过氯乙烯的工人和4名监测到接触过氯乙烯的工人（受雇于巴斯夫公司）；（2）20名有氯乙烯疾病症状但接触情况不明的工人以及1例因接触氯乙烯导致的血管肉瘤病例（未受雇于巴斯夫公司）；以及（3）吸入2500 ppm或5000 ppm氯乙烯后，或腹腔注射300 mg/kg或600 mg/kg氯乙烯后的中国仓鼠骨髓细胞。出现氯乙烯疾病症状的先证者组、唯一存活的血管肉瘤病例以及动物试验表明，与对照组相比，畸变率显著增加。
