Menon M K, Vivonia C A
Eur J Pharmacol. 1981 Dec 3;76(2-3):223-7. doi: 10.1016/0014-2999(81)90504-5.
Intraperitoneal administration of apomorphine caused hypothermia in mice. Pretreatment with the serotonin (5-HT) receptor antagonists methysergide (3 mg/kg), cinanserin (10 mg/kg) or brom-LSD (3 mg/kg) potentiated this response of apomorphine. Brain 5-HT depletion by p-chlorophenylalanine caused similar modification. On the contrary, the 5-HT receptor agonists quipazine (3 mg/kg) and MK-212 (3 mg/kg), significantly blocked apomorphine hypothermia. It was concluded that 5-HT modulates the dopamine (DA)-mediated body temperature changes and that drug-induced alterations in the brain 5-HT function modify apomorphine-induced hypothermia in a predictable manner. One mg/kg dose of lysergic acid diethylamide (LSD) blocked apomorphine hypothermia. The apomorphine-blocking effect of both quipazine and LSD developed tolerance. Moreover, LSD showed cross tolerance with quipazine. It was concluded that the hypothermia-blocking property of LSD resides on its ability to activate the hypothalamic 5-HT receptors.
腹腔注射阿扑吗啡可使小鼠体温降低。用5-羟色胺（5-HT）受体拮抗剂甲基麦角新碱（3毫克/千克）、辛那色林（10毫克/千克）或溴化麦角酰二乙胺（3毫克/千克）预处理可增强阿扑吗啡的这种反应。对氯苯丙氨酸使脑内5-HT耗竭也产生类似的改变。相反，5-HT受体激动剂喹哌嗪（3毫克/千克）和MK-212（3毫克/千克）可显著阻断阿扑吗啡引起的体温降低。得出的结论是，5-HT调节多巴胺（DA）介导的体温变化，药物引起的脑内5-HT功能改变以可预测的方式改变阿扑吗啡诱导的体温降低。1毫克/千克剂量的麦角酸二乙酰胺（LSD）可阻断阿扑吗啡引起的体温降低。喹哌嗪和LSD的阿扑吗啡阻断作用均产生耐受性。此外，LSD与喹哌嗪表现出交叉耐受性。得出的结论是，LSD的体温降低阻断特性在于其激活下丘脑5-HT受体的能力。
