狭叶蕊木的抗癌吲哚生物碱。

Anticancer indole alkaloids of Rhazya stricta.

作者信息

Mukhopadhyay S, Handy G A, Funayama S, Cordell G A

出版信息

J Nat Prod. 1981 Nov-Dec;44(6):696-700. doi: 10.1021/np50018a014.

Abstract

The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.

摘要

夹竹桃科植物沙漠玫瑰（Rhazya stricta）的叶和根产生了四种吲哚生物碱。分离得到的其中三种，即瓦莱西乔胺（1）、苏瓦林（3）和四氢南美粟碱（4），具有细胞毒性活性；多神经氨酸（2）此前未在该物种中报道过。四氢南美粟二醇（5）、其乙酸酯6和二去甲氧基羰基 - 四氢南美粟碱（7）通过化学反应由四氢南美粟碱（4）制备而成。二醇5具有高度细胞毒性。