Quetin-Leclercq J
Laboratoire de Pharmacognosie, Université de Liège, Belgique.
J Pharm Belg. 1994 May-Jun;49(3):181-92.
Many drugs are derived from active molecules isolated from plants or micro-organisms. Nevertheless, a lot of species have not yet been studied; they constitute an important source of new structures that could possess interesting pharmacological activities and/or original modes of action, for example in the field of anticancer or antiparasitic drugs (taxol, artemisinin, swainsonine, camptothecin,...). Among all the bioactive natural products, we studied more particularly indole alkaloids extracted from different tropical Strychnos species. Several new alkaloids have been isolated from cytotoxic crude extracts. Some of them possess interesting cytotoxic, antitumor or antiparasitic properties. We also realised molecular modelling studies in order to explain the activity of usambarensine.
许多药物源自从植物或微生物中分离出的活性分子。然而，许多物种尚未得到研究；它们构成了新结构的重要来源，这些新结构可能具有有趣的药理活性和/或独特的作用方式，例如在抗癌或抗寄生虫药物领域（紫杉醇、青蒿素、苦马豆素、喜树碱等）。在所有生物活性天然产物中，我们特别研究了从不同热带马钱属物种中提取的吲哚生物碱。从具有细胞毒性的粗提物中分离出了几种新的生物碱。其中一些具有有趣的细胞毒性、抗肿瘤或抗寄生虫特性。我们还进行了分子建模研究，以解释乌桑巴雷辛的活性。
