Macrophage disappearance reaction in Rana esculenta induced by specific antigen and rabbit lymphokines.

Macrophage disappearance reaction was induced by intraperitoneal injections of specific antigens in Rana esculenta sensitized by bovine gamma globulin and Mycobacterium bovis BCG. Rabbit lymphokines derived from concanavalin A stimulated blood lymphocytes injected intraperitoneally were able to induce macrophage disappearance reaction in normal Rana esculenta. This suggests that mammalian lymphokines are capable of acting in amphibia. Mammalian lymphokines have not an exclusive class-specificity in vertebrates.