在用半抗原-载体偶联物免疫之前对巨噬细胞进行刺激和抑制。
Stimulation and inhibition of macrophages prior to immunization with a hapten-carrier conjugate.
作者信息
Neveu P J
出版信息
Immunology. 1977 Aug;33(2):269-73.
Abstract
Delayed hypersensitivity reactions and antibody-mediated reactions to the carrier and to the hapten have been studied in animals treated with BCG or/and trypan blue before immunization with a hapten-carrier complex. The results show that it is possible to induce, with BCG, at the beginning of the response, an antigenic competition between hapten and carrier moieties of the antigen molecule. Macrophages which modulate the response to the hapten-carrier complex by acting both on T cells involved in cellular immunity and those involved in antibody synthesis, appear to be the target of antigenic competition.
摘要
在用半抗原 - 载体复合物免疫之前，用卡介苗或/和台盼蓝处理过的动物中，已对迟发型超敏反应以及针对载体和半抗原的抗体介导反应进行了研究。结果表明，在反应开始时用卡介苗有可能诱导抗原分子的半抗原和载体部分之间的抗原竞争。通过作用于参与细胞免疫的T细胞和参与抗体合成的T细胞来调节对半抗原 - 载体复合物反应的巨噬细胞，似乎是抗原竞争的靶点。
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Macrophage-digested antigen as inducer of delayed hypersensitivity.巨噬细胞消化的抗原作为迟发型超敏反应的诱导剂。
J Exp Med. 1971 Mar 1;133(3):494-505. doi: 10.1084/jem.133.3.494.
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Separation of T effector cells in humoral and cellular immunity.体液免疫和细胞免疫中T效应细胞的分离。
Nature. 1974 Dec 13;252(5484):607-8. doi: 10.1038/252607a0.
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Dissociation of T cell helper function and delayed hypersensitivity.T细胞辅助功能与迟发型超敏反应的分离
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Macrophages bearing hapten-carrier molecules as foci inducers for T and B lymphocyte interaction.带有半抗原载体分子的巨噬细胞作为T和B淋巴细胞相互作用的灶性诱导物。
Eur J Immunol. 1974 Jan;4(1):1-4. doi: 10.1002/eji.1830040102.
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Heterocytolysis by macrophages activated by bacillus Calmette-Guérin: lysosome exocytosis into tumor cells.卡介苗激活的巨噬细胞介导的异细胞溶解：溶酶体向肿瘤细胞的胞吐作用。
Science. 1974 Apr 26;184(4135):468-71. doi: 10.1126/science.184.4135.468.
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Carrier function in immune deviation.载体在免疫偏离中的作用。
J Immunol. 1974 Mar;112(3):1264-6.
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Immunogenicity of macrophage-bound antigens: the requirement for hapten and carrier determinants to be on the same molecule for T and B lymphocyte collaboration.巨噬细胞结合抗原的免疫原性：T 细胞和 B 淋巴细胞协作时半抗原和载体决定簇位于同一分子上的必要性。
Eur J Immunol. 1973 Sep;3(9):559-63. doi: 10.1002/eji.1830030907.
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