Jaillard J, Sezille G, Dewailly P, Fruchart J C
Ann Med Interne (Paris). 1977 Oct;128(10):739-44.
Detected using a method involving gradient electrophoresis on polyacrylamide gel, the presence of a high level of an Lp(a) was demonstrated in 17% of control subjects and 39% oh hyperlipidaemic subjects explored. The difference appeared to be particularly significant in subjects with a pure hypercholesterolaemia (type IIA) or dominant hypercholesterolaemia (type IIB), which may be accounted for by the antigenic communities and related substances in the lipid composition uniting Lp(a) to LDL. The association of frank atherosclerosis with the hyperlipidaemia substantially increased the frequency of high levels of circulating Lp(a). A combined elevation of levels of Lp(a) and LDL would seem to be associated with a particular atherogenic power.
采用一种涉及聚丙烯酰胺凝胶梯度电泳的方法检测发现，在17%的对照受试者和39%接受检查的高脂血症受试者中存在高水平的Lp(a)。这种差异在单纯高胆固醇血症（IIA型）或显性高胆固醇血症（IIB型）患者中似乎尤为显著，这可能是由于脂质成分中的抗原群落及相关物质将Lp(a)与低密度脂蛋白（LDL）结合所致。明显的动脉粥样硬化与高脂血症的关联显著增加了循环中Lp(a)高水平的频率。Lp(a)和LDL水平的联合升高似乎与一种特殊的致动脉粥样硬化能力有关。
