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眼球运动障碍与双侧丘脑 - 底丘脑梗死(作者译)

[Oculocephalomotor disorders and bilateral thalamo-subthalamic infarction (author's transl)].

作者信息

Petit H, Rousseaux M, Clarisse J, Delafosse A

出版信息

Rev Neurol (Paris). 1981;137(11):709-22.

PMID:7336023
Abstract

A 33-year-old woman on oral contraceptives suddenly developed neurological disorders characterised by decreased alertness, absence of motor and verbal spontaneity, anterograde amnesia with difficulties in verbal and visual learning. She also presented paralysis of upwards and downwards ocular movements affecting mainly saccadic movements while convergence was normal. An initial almost total absence of spontaneous head movements and later an impossibility to carry out downwards movements of the head. This apparently represents a syndrome still not reported in human pathology. The clinical course was favourable. CT scan suggested the presence of a paramedian infarct of the region supplied by the thalamosubthalamic artery of the type II b of Percheron. An analogy is suggested between these disorders of oculocephalomotor behaviour and those observed by Denny-Brown in experimental bilateral retrorubric lesions. The possibility of a lesion in the internal thalamic nucleis and the adjacent subthalamic region is considered.

摘要

一名33岁服用口服避孕药的女性突然出现神经功能障碍,表现为警觉性降低、运动和言语自发性缺失、顺行性遗忘伴言语和视觉学习困难。她还出现了向上和向下眼球运动麻痹,主要影响扫视运动,而集合正常。最初几乎完全没有自发的头部运动,后来无法进行头部向下运动。这显然代表了一种在人类病理学中尚未报道的综合征。临床病程良好。CT扫描提示存在由佩谢龙丘脑底动脉II b型供血区域的旁正中梗死。有人提出这些眼动头动行为障碍与丹尼-布朗在实验性双侧红核后病变中观察到的障碍之间存在相似性。考虑到丘脑内核和相邻丘脑底区域存在病变的可能性。

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