Aymard J P, Lederlin P, Witz F, Colomb J N, Faure G, Guerci O, Herbeuval R
Scand J Haematol. 1981 Apr;26(4):330-2. doi: 10.1111/j.1600-0609.1981.tb01669.x.
We report a case of multiple myeloma in a 48-year-old woman treated with phenytoin for 55 months. This association may be fortuitous. The depressive effect of phenytoin on the immune responses, however, could account for the occurrence of the dysglobulinaemia. This case points out the need for periodic examination of serum proteins in patients chronically treated with hydantoin derivatives.
我们报告一例48岁女性多发性骨髓瘤患者，该患者接受苯妥英治疗55个月。这种关联可能是偶然的。然而，苯妥英对免疫反应的抑制作用可能是导致球蛋白血症发生的原因。该病例指出，长期接受乙内酰脲衍生物治疗的患者需要定期检查血清蛋白。
