Wadenvik H, Eriksson K A, Safai-Kutti S, Swedberg K, Kutti J
Scand J Haematol. 1981 May;26(5):359-63. doi: 10.1111/j.1600-0609.1981.tb01676.x.
The aim was to investigate whether in the acute stage of myocardial infarction (MI) platelet activation, as measured by plasma platelet factor 4 (PF-4), excluding that in ischaemic heart disease (IHD) is taking place. Over a period of 4 d the plasma levels of PF-4 were determined on 44 consecutive patients admitted to a coronary care unit with suspected MI. 21 of them had a definite acute MI (group 1), and 13 had evidence of IHD but no MI (group 2). In the remaining 10 subjects there was no evidence of either MI or IHD. On the first day the mean plasma PF-4 concentrations in group 1 and 2 patients were 11,8 +/- 1.1 and 15.0 +/- 2.3 ng/ml, respectively; the difference between means was not statistically significant. A peak mean PF-4 for group 1 patients (17.5 +/- 4.6 ng/ml) was recorded on the second day of study. The corresponding value for group 2 patients was lower, but not significantly so. In the latter subjects no peak PF-4 was recorded. During the last 2 d of study the plasma PF-4 concentrations tended to decrease, but the means for the 2 groups did not differ statistically. Thus, at no point in time was there a significant difference between the PF-4 values for MI and IHD patients present.
目的是研究在心肌梗死（MI）急性期，通过血浆血小板因子4（PF-4）测定的血小板活化情况（不包括缺血性心脏病（IHD）中的情况）是否正在发生。在4天的时间里，对44名连续入住冠心病监护病房且疑似患有MI的患者测定了PF-4的血浆水平。其中21人确诊为急性MI（第1组），13人有IHD证据但无MI（第2组）。其余10名受试者既无MI也无IHD证据。第一天，第1组和第2组患者的平均血浆PF-4浓度分别为11.8±1.1和15.0±2.3 ng/ml；均值之间的差异无统计学意义。在研究的第二天记录到第1组患者的平均PF-4峰值为（17.5±4.6 ng/ml）。第2组患者的相应值较低，但差异不显著。在后者中未记录到PF-4峰值。在研究的最后2天，血浆PF-4浓度趋于下降，但两组的均值在统计学上无差异。因此，MI患者和IHD患者的PF-4值在任何时间点均无显著差异。
