Kutti J, Safai-Kutti S, Zaroulis C G, Good R A
Acta Haematol. 1980;64(1):1-5. doi: 10.1159/000207202.
The plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) were determined in patients with various hematologic malignancies, and the results were related to simultaneously determined venous platelet counts. All studied patients were in a steady state. The plasma beta-TG concentrations were determined on 69 occasions and the values ranged from 0 to 82 ng/ml. In 33 instances, the venous platelet count was <25 x 10 (9/1) and in two thirds of these samples beta-TG was undedectable. The highest values for plasma beta-TG were found in patients with the highest venous platelet counts. A highly significant correlation (r=0.77, p <0.001) between the values for plasma beta-TG and venous platelet count was present. The plasma concentrations for PF-4 ranged from 0 to 50 ng/ml. Similarly, there was a highly significant relationship (r=0.78, p<0.001) between the values for PF-4 and venous platelet concentration. We conclude, if the plasma levels of beta-TG and PF-4 are used as markers of platelet activation in vivo, it is necessary to simultaneously consider the platelet concentration in the collected blood.
测定了各类血液系统恶性肿瘤患者的血浆β-血小板球蛋白（β-TG）和血小板因子4（PF-4）水平，并将结果与同时测定的静脉血小板计数进行关联。所有研究患者均处于稳定状态。共69次测定血浆β-TG浓度，其值范围为0至82 ng/ml。33例中静脉血小板计数<25×10⁹/L，其中三分之二的样本β-TG检测不到。血浆β-TG的最高值见于静脉血小板计数最高的患者。血浆β-TG值与静脉血小板计数之间存在高度显著的相关性（r = 0.77，p<0.001）。PF-4的血浆浓度范围为0至50 ng/ml。同样，PF-4值与静脉血小板浓度之间也存在高度显著的关系（r = 0.78，p<0.001）。我们得出结论，如果将血浆β-TG和PF-4水平用作体内血小板活化的标志物，则有必要同时考虑所采集血液中的血小板浓度。
