A genetic factor controlling morphogenesis of the laryngotracheo-esophageal complex the mouse.

A new autosomal, recessive lethal mutation in the mouse cause failure of division of the embryonic foregut into totally separate digestive and respiratory ducts. The newborn homozygote has a cleft that extends between the laryngotracheal and esophageal tubes, allowing excessive air to pass into the stomach and subsequently into the peritoneal cavity. This mutation has been designated lec (laryngotracheo-esophageal cleft). The common region shared by the respiratory and digestive tubes has features characteristic of both structures. Development of cartilage around the laryngotracheo-esophageal complex is also affected in the mutant.