Slovak A J
Thorax. 1981 Dec;36(12):906-9. doi: 10.1136/thx.36.12.906.
A prevalence study of occupational asthma was carried out by questionnaire in 1980 among a group of 151 workers who had been exposed to azodicarbonamide dust in the process of its manufacture. Twenty-eight (18.5%) people without previous asthma gave a history of episodes of late onset asthma after exposure to azodicarbonamide. Re-exposure caused repetition and worsening of symptoms. Immediate removal from further exposure resulted in rapid cessation of symptoms without further recurrence. Seven of 13 sensitised individuals who were still exposed three months after the onset of disease developed prolonged airways hyperreactivity to common environmental irritants. Azodicarbonamide should be excluded as a causative agent in plastics and rubber industry workers complaining of occupational asthma.
1980年,通过问卷调查对一组151名在偶氮二甲酰胺制造过程中接触过其粉尘的工人进行了职业性哮喘患病率研究。28名(18.5%)既往无哮喘的人在接触偶氮二甲酰胺后出现迟发性哮喘发作史。再次接触导致症状复发和加重。立即停止进一步接触可使症状迅速缓解且不再复发。在疾病发作三个月后仍暴露的13名致敏个体中有7人对常见环境刺激物产生了持续性气道高反应性。对于抱怨职业性哮喘的塑料和橡胶行业工人,应排除偶氮二甲酰胺作为致病因素。