Weniger P
Toxicology. 1981;22(1):53-8. doi: 10.1016/0300-483x(81)90007-x.
Chinese Hamster ovary (CHO) cells were treated with 5- or 8-methoxypsoralen (MOP) in combination with longwave UV light (UVA). The toxicity and the action of these substances on DNA synthesis as well as well as the nature of damage caused by them in combination with UVA light and the ability of the cells to repair this damage was examined. 8-MOP induces interstrand crosslinks within the DNA when applied together with UVA light. It decreases the rate of DNA synthesis at sublethal doses. 5-MOP shows the same effect though it induces virtually no DNA crosslinks. The repair of damage process. It is not quite complete at 24 h. Neither compound has an effect on CHO cells when applied without UVA light.
用5-甲氧基补骨脂素（MOP）或8-甲氧基补骨脂素与长波紫外线（UVA）联合处理中国仓鼠卵巢（CHO）细胞。检测了这些物质的毒性、对DNA合成的作用、它们与UVA光联合造成的损伤性质以及细胞修复这种损伤的能力。8-甲氧基补骨脂素与UVA光一起使用时会诱导DNA链间交联。在亚致死剂量下，它会降低DNA合成速率。5-甲氧基补骨脂素也有相同的效果，尽管它几乎不诱导DNA交联。损伤修复过程在24小时时并不完全。当不使用UVA光单独应用这两种化合物时，对CHO细胞均无影响。
