衰老的细胞基础。
The cellular basis of aging.
作者信息
Scoggin C H
出版信息
West J Med. 1981 Dec;135(6):521-5.
Abstract
Normal cells have only a finite life span before they die. The process known as aging may occur as a result of continued damage to the cell or as a result of expression of predetermined information within the genetic structure of the cell. Both processes lead to progressive cellular dysfunction which is evidenced by the organs of the body as aging. By understanding how individual cells age we will gain insight into how the body as a whole ages. The impact of such knowledge on science and society is a matter of both conjecture and concern.
摘要
正常细胞在死亡前只有有限的寿命。被称为衰老的过程可能是由于细胞持续受损，或者是由于细胞遗传结构中预定信息的表达。这两个过程都会导致细胞功能逐渐失调，身体的器官会将其表现为衰老。通过了解单个细胞如何衰老，我们将深入了解整个身体是如何衰老的。这种知识对科学和社会的影响既是一个猜测的问题，也是一个令人担忧的问题。
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本文引用的文献
1
Alzheimer's disease, trisomy 21, and myeloproliferative disorders: associations suggesting a genetic diathesis.
Science. 1977 Apr 15;196(4287):322-3. doi: 10.1126/science.196.4287.322.
2
The maintenance of the accuracy of protein synthesis and its relevance to ageing.
Proc Natl Acad Sci U S A. 1963 Apr;49(4):517-21. doi: 10.1073/pnas.49.4.517.
3
The serial cultivation of human diploid cell strains.
Exp Cell Res. 1961 Dec;25:585-621. doi: 10.1016/0014-4827(61)90192-6.
4
Aging: present status of our chemical knowledge.
J Am Geriatr Soc. 1962 Feb;10:125-39. doi: 10.1111/j.1532-5415.1962.tb00265.x.
5
Altered enzymes in ageing human fibroblasts.
Nature. 1972 Jul 7;238(5358):26-30. doi: 10.1038/238026a0.
6
Future directions in aging research.
Proc Soc Exp Biol Med. 1980 Nov;165(2):206-14. doi: 10.3181/00379727-165-40959.
7
Nutritional probe of the aging process.
Fed Proc. 1980 Dec;39(14):3178-82.
8
Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1001-3. doi: 10.1073/pnas.78.2.1001.
9
The immune system and the aging process in man.
Proc Soc Exp Biol Med. 1980 Nov;165(2):200-5. doi: 10.3181/00379727-165-40958.
10
Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.
J Biol Chem. 1981 Jul 25;256(14):7181-6.
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