衰老人类成纤维细胞中的酶变化
Altered enzymes in ageing human fibroblasts.
作者信息
Holliday R, Tarrant G M
机构信息
National Institute for Medical Research, Mill Hill, London NW7 1AA.
出版信息
Nature. 1972 Jul 7;238(5358):26-30. doi: 10.1038/238026a0.
DOI:10.1038/238026a0
PMID:12635262
Abstract
Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.
摘要
二倍体人类成纤维细胞在培养的寿命末期积累热不稳定酶。RNA碱基类似物5-氟尿嘧啶会诱导早衰，早衰之前会出现酶的改变。这些观察结果支持了奥格尔的衰老“错误灾难”理论。
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