Rother P, Peil J, Dettmer M
Z Alternsforsch. 1981;36(6):489-93.
By the point counting method and empirical regression we investigated the aging changes in volume densities of histological structures in 43 human thyroid glands and in 42 human submandibular glands. Especially we wanted to show, how the change of the most important errors influences the shape of our aging curves. We had to take into consideration the statistical error, the error caused by the structural heterogenity, and the error caused by the interindividual variability. It was shown, that an increase of the exactness of measuring as well as a consideration of the structural heterogenity in the organs do not change the course of aging curves and 42 or 43 cases were sufficient for our investigations.
通过点数法和经验回归，我们研究了43个人类甲状腺和42个人类下颌下腺组织结构体积密度的老化变化。特别是，我们想展示最重要误差的变化如何影响我们老化曲线的形状。我们必须考虑统计误差、结构异质性引起的误差以及个体间变异性引起的误差。结果表明，测量精度的提高以及对器官结构异质性的考虑并不会改变老化曲线的进程，42或43个病例对于我们的研究就足够了。
