Datta D V, Khuroo M S, Mattocks A R, Aikat B K, Chhuttani P N
Postgrad Med J. 1978 Aug;54(634):511-5. doi: 10.1136/pgmj.54.634.511.
Six cases are described of veno-occlusive disease (VOD) after medicinal herb ingestion. The herb Heliotropium eichwaldii, taken by three patients, was found to contain the toxic pyrrolizidine alkaloid, heliotrine. Two patients presented with fulminant hepatic failure while the other four patients had a clinical picture suggestive of decompensated cirrhosis. The medical use of this herb may possibly be responsible for a significant proportion of acute and chronic liver disease in India, making it of public health importance.
本文描述了6例因摄入草药后发生的静脉闭塞性疾病（VOD）。3例患者服用的紫草科植物被发现含有有毒的吡咯里西啶生物碱——天芥菜碱。2例患者表现为暴发性肝衰竭，另外4例患者的临床表现提示肝硬化失代偿。这种草药的医学应用可能是印度相当一部分急慢性肝病的病因，因此具有公共卫生重要性。
