Reboul M C, Coiffet J, Forestier J Y, Cambazard F, Coeur P, Colomb D
Ann Dermatol Venereol. 1981;108(12):951-8.
The authors report the observation of pyoderma gangrenosum (P. G.) leading to the discovery of an underlying biclonal gammapathy, which despite the absence of bony lesions, almost certainly represents a malignant myeloma. The authors have reviewed the different known associations with pyoderma gangrenosum, with special reference to benign and malignant gammapathies. Rare cases of biclonal gammapathies with pyoderma gangrenosum have been published but none of a malignant nature. This therefore appears to be the first reported cases. The authors are aware of the reported tendency of pyoderma gangrenosum lesions to appear in areas of previous trauma, as may be the case in this patient. Finally systemic corticosteroid therapy produced a rapid remission of the skin lesions, but with the reactivation of known treated pulmonary tuberculosis.
作者报告了坏疽性脓皮病（P.G.）的观察情况，该观察导致发现了一种潜在的双克隆丙种球蛋白病，尽管没有骨病变，但几乎可以肯定这代表了一种恶性骨髓瘤。作者回顾了与坏疽性脓皮病的不同已知关联，特别提及了良性和恶性丙种球蛋白病。已发表了罕见的伴有坏疽性脓皮病的双克隆丙种球蛋白病病例，但均无恶性性质。因此，这似乎是首例报告病例。作者注意到坏疽性脓皮病病变有出现在既往创伤部位的报道倾向，该患者可能就是这种情况。最后，全身皮质类固醇治疗使皮肤病变迅速缓解，但已知的已治疗肺结核复发。
