Barthel E
Arch Geschwulstforsch. 1981;51(7):579-85.
In a cohort study to assess the frequency of malignant neoplasms among persons exposed to pesticides, data were collected for 1791 pesticide-exposed agricultural technicians from all regions of the GDR with the exception of Berlin. A total of 169 malignant neoplasms occurred during the study period of which 59 were bronchial, 21 stomach, 19 skin and 11 prostatic. Bronchial carcinoma in the exposed group occurred twice as often as expected based on average GDR experience. There was no increase in tumor incidence at the remaining sites with the exception of skin carcinoma which showed a morbidity of 1.2 times the expected. Of the bronchial carcinomas 54% were smallcell or undifferentiated and 30% were squamous cell carcinomas. The average exposure time to pesticides among the bronchial carcinoma cases was 13.6 +/- 5.1 (range 6-23) years. The average latent time between the onset of exposure and clinically or roentgenologically evident bronchial carcinoma was 17.5 +/- 6.4 (range 6-29) years. Since the smoking habits of the exposed group did not differ from those of the general population, an etiologic role for the pesticide exposure is suspected for the bronchial carcinoma cases. Based on individual exposure experience, experimental data and the usage of these agents in the GDR, the agents of most concern are the arsenic-containing compounds, DDT, HCH, and phenoxy acids.
在一项评估接触农药人群中恶性肿瘤发生频率的队列研究中，收集了来自民主德国除柏林以外所有地区的1791名接触农药的农业技术人员的数据。在研究期间共发生了169例恶性肿瘤，其中59例为支气管癌，21例为胃癌，19例为皮肤癌，11例为前列腺癌。接触组中的支气管癌发生率是根据民主德国的平均情况预期发生率的两倍。除皮肤癌发病率为预期的1.2倍外，其余部位的肿瘤发病率均未增加。在支气管癌病例中，54%为小细胞癌或未分化癌，30%为鳞状细胞癌。支气管癌病例接触农药的平均时间为13.6±5.1（范围6 - 23）年。从开始接触到临床上或放射学上明显的支气管癌之间的平均潜伏期为17.5±6.4（范围6 - 29）年。由于接触组的吸烟习惯与普通人群没有差异，因此怀疑支气管癌病例中农药接触具有病因学作用。根据个体接触经验、实验数据以及这些制剂在民主德国的使用情况，最值得关注的制剂是含砷化合物、滴滴涕、六六六和苯氧基酸。
