White N, Brown Z, Yachnin M
Pharmacol Biochem Behav. 1978 Nov;9(5):603-8. doi: 10.1016/0091-3057(78)90210-1.
Rats with self-stimulation electrodes in the medial part of lateral hypothalamus (LH) or in the lateral part of LH were trained to bar press, to run in a continuous, square-shaped runway, and to move their tails from side to side while otherwise restrained, all using LH stimulation on an FI 2 sec schedule as the reinforcement. At low doses of pimozide (a dopaminergic blocker) or of FLA-57 (a dopamine beta-hydroxylase inhibitor) different effects on rates of responding were observed on each of the three tasks at the two electrode placements, indicating that the rate reductions were not the results of specific performance effects of the drugs. The patterns of rate changes suggested that the effects of LH stimulation on behavior in the runway were primarily, but not exclusively mediated by a dopaminergic system; that the effects of LH stimulation on tail movement were primarily, but not exclusively mediated by a noradrenergic system; and that the effect of LH stimulation on bar pressing was mediated by both, or either of these substrates. These results suggest that the reinforcement of behavior by LH stimulation is flexibly mediated by at least two different neural systems.
将自我刺激电极植入下丘脑外侧区（LH）内侧部分或LH外侧部分的大鼠，接受训练以按压杠杆、在连续的方形跑道上奔跑以及在其他情况下受到约束时左右摆动尾巴，所有这些训练均以每2秒一次的LH刺激作为强化物。在低剂量的匹莫齐特（一种多巴胺能阻滞剂）或FLA - 57（一种多巴胺β - 羟化酶抑制剂）作用下，在两个电极植入位置对三项任务中的每一项任务的反应率都观察到了不同的影响，这表明反应率的降低并非药物特定性能影响的结果。反应率变化模式表明，LH刺激对跑道行为的影响主要但并非完全由多巴胺能系统介导；LH刺激对尾巴运动的影响主要但并非完全由去甲肾上腺素能系统介导；LH刺激对按压杠杆的影响由这两种底物中的一种或两种介导。这些结果表明，LH刺激对行为的强化作用至少由两种不同的神经系统灵活介导。
