Messiha F S
Pharmacol Biochem Behav. 1978 Nov;9(5):647-51. doi: 10.1016/0091-3057(78)90216-2.
The effects of RbCl and CsCl on voluntary intake of ethanol solution by rats preferring ethanol solution 5% (w/w) over water as the drinking fluid was studied as a function of the dose given and the vehicle injected. Administration of RbCl or CsCl, 0.5 mEq/kg/day or 1.5 mEq/kg/day for three consecutive days, did not alter amounts of ethanol consumed. Repeated administration of RbCl or CsCl, 3.0 mEq/kg/day for three days, produced some moderate reduction in ethanol consumption. Simultaneous injection of RbCl (1.5 mEq/kg) and CsCl (1.5 mEq/kg) resulted in greater and profound lasting decrease in ethanol drinking. The later treatment did not alter specific activities of rat liver alcohol- and aldehyde dehydrogenase from saline treated controls. In general, dissolving the chloride salt of the alkali metals in saline resulted in greater effects on ethanol drinking than that determined after identical dose injected with water as the vehicle. The possible mechanism(s) underlying the effects of alkali metal salts used are suggested.
研究了RbCl和CsCl对偏好5%（w/w）乙醇溶液而非水作为饮用液体的大鼠自愿摄入乙醇溶液的影响，该影响是给予剂量和注射载体的函数。连续三天每天给予0.5 mEq/kg或1.5 mEq/kg的RbCl或CsCl，并未改变乙醇的摄入量。连续三天每天给予3.0 mEq/kg的RbCl或CsCl，会使乙醇摄入量有一定程度的适度减少。同时注射RbCl（1.5 mEq/kg）和CsCl（1.5 mEq/kg）会导致乙醇饮用量更大且持续时间更长的显著减少。后一种处理并未改变盐水处理对照组大鼠肝脏乙醇脱氢酶和醛脱氢酶的比活性。总体而言，将碱金属的氯化物盐溶解在盐水中比以水作为载体注射相同剂量后对乙醇饮用的影响更大。文中提出了所使用的碱金属盐产生影响的可能机制。
