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沙林和梭曼在稀水溶液中的稳定性及醋酸根离子的催化作用

The stability of sarin and soman in dilute aqueous solutions and the catalytic effect of acetate ion.

作者信息

Ellin R I, Groff W A, Kaminskis A

出版信息

J Environ Sci Health B. 1981;16(6):713-7. doi: 10.1080/03601238109372290.

DOI:10.1080/03601238109372290
PMID:7338595
Abstract

The hydrolysis of aqueous solutions of organophosphonate compounds such as sarin and soman is a critical factor in biochemical and therapeutic studies. The ability to dilute and transport these compounds with assurance of their purity is imperative to the integrity of such studies. An enzymic method has been used to measure low levels of organophosphonates. Maximum stability data were determined in aqueous and isotonic saline solutions. Acetate ion was found to significantly accelerate hydrolysis.1

摘要

诸如沙林和梭曼等有机膦酸酯化合物水溶液的水解是生化和治疗研究中的一个关键因素。在确保这些化合物纯度的前提下对其进行稀释和运输的能力对于此类研究的完整性至关重要。一种酶法已被用于测定低水平的有机膦酸酯。在水溶液和等渗盐溶液中测定了最大稳定性数据。发现醋酸根离子能显著加速水解。1

相似文献

1
The stability of sarin and soman in dilute aqueous solutions and the catalytic effect of acetate ion.沙林和梭曼在稀水溶液中的稳定性及醋酸根离子的催化作用
J Environ Sci Health B. 1981;16(6):713-7. doi: 10.1080/03601238109372290.
2
Stability of aqueous solutions of sarin and soman: influence of concentration and an equation for determining concentration.沙林和梭曼水溶液的稳定性:浓度的影响及浓度测定方程
Bull Environ Contam Toxicol. 1984 Jul;33(1):1-5. doi: 10.1007/BF01625503.
3
Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer: implications for analytical and toxicological investigations.在磷酸盐缓冲液中,沙林、梭曼和环沙林等神经毒剂形成类似焦磷酸盐的加合物:对分析和毒理学研究的意义。
Toxicol Lett. 2011 Jan 15;200(1-2):34-40. doi: 10.1016/j.toxlet.2010.10.011. Epub 2010 Oct 25.
4
Analysis of soman and sarin in blood utilizing a sensitive gas chromatography-mass spectrometry method.
J Chromatogr. 1985 May 17;324(1):163-72. doi: 10.1016/s0021-9673(01)81315-7.
5
Revisiting the reactivity of oximate alpha-nucleophiles with electrophilic phosphorus centers. Relevance to detoxification of sarin, soman and DFP under mild conditions.重新审视肟基α-亲核试剂与亲电磷中心的反应活性。与沙林、梭曼和二异丙基氟磷酸酯在温和条件下的解毒作用的相关性。
Org Biomol Chem. 2006 Dec 7;4(23):4352-63. doi: 10.1039/b609658c. Epub 2006 Oct 26.
6
Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds--characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.稳定的神经毒剂沙林、梭曼和环沙林与 TRIS、TES 和相关缓冲化合物的加合物 - 通过 LC-ESI-MS/MS 和 NMR 的表征及对分析化学的影响。
J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 15;878(17-18):1382-90. doi: 10.1016/j.jchromb.2010.01.043. Epub 2010 Feb 2.
7
Monitoring the hydrolysis of toxic organophosphonate nerve agents in aqueous buffer and in bicontinuous microemulsions by use of diisopropyl fluorophosphatase (DFPase) with (1)H- (31)P HSQC NMR spectroscopy.利用(1)H-(31)P HSQC NMR 光谱法监测在水缓冲液和双连续微乳液中用二异丙基氟膦酸酯酶(DFPase)水解有毒的有机膦酸酯神经毒剂。
Anal Bioanal Chem. 2010 Feb;396(3):1213-21. doi: 10.1007/s00216-009-3299-2. Epub 2009 Nov 27.
8
Variability of neurotoxicity of and lack of tolerance to the anticholinesterases soman and sarin in the rat.大鼠体内抗胆碱酯酶索曼和沙林的神经毒性变异性及耐受性缺失
Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):415-30.
9
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin.人血清对氧磷酶多态性的影响在使用重氮磷、梭曼和沙林后会发生逆转。
Nat Genet. 1996 Nov;14(3):334-6. doi: 10.1038/ng1196-334.
10
Stereochemical specificity of organophosphorus acid anhydrolase toward p-nitrophenyl analogs of soman and sarin.有机磷酸酐酶对梭曼和沙林对硝基苯基类似物的立体化学特异性。
Bioorg Chem. 2001 Feb;29(1):27-35. doi: 10.1006/bioo.2000.1189.

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3
Safe disposal of diisopropyl fluorophosphate (DFP).
氟磷酸二异丙酯(DFP)的安全处置
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4
Stability of aqueous solutions of sarin and soman: influence of concentration and an equation for determining concentration.沙林和梭曼水溶液的稳定性:浓度的影响及浓度测定方程
Bull Environ Contam Toxicol. 1984 Jul;33(1):1-5. doi: 10.1007/BF01625503.
5
The stability of soman and its stereoisomers in aqueous solution: toxicological considerations.梭曼及其立体异构体在水溶液中的稳定性:毒理学考量
Arch Toxicol. 1986 Dec;59(4):261-5. doi: 10.1007/BF00290548.