Broomfield C A, Lenz D E, MacIver B
Arch Toxicol. 1986 Dec;59(4):261-5. doi: 10.1007/BF00290548.
The paucity of information regarding the characteristics of soman (pinacolyl methylphosphonofluoridate) in aqueous solution has limited its use as a toxicological or pharmacological reagent. We report here on the stability of soman under conditions in which it may normally be found during use and storage in the laboratory. Solutions of 1 mM soman in normal saline were not hydrolyzed after 5 months of storage at -90 degrees C. Samples that were repeatedly thawed but not allowed to warm to room temperature and then immediately refrozen showed no apparent hydrolysis. Portions of the same solution, stored in the refrigerator just above freezing, exhibited 50% hydrolysis after 150 days. When portions of this solution were stored at 21 degrees C, the time for 50% hydrolysis was in excess of 5 days. This rate of hydrolysis was the same for all four of the soman stereoisomers. In buffered solutions at pH 7.4, 8.0 and 8.6 the half-times were 6.6, 3.2 and 2.2 h at 27 degrees C and 4.8, 1.6 and 1.2 h at 37 degrees C, respectively. Hydrolysis rates were not significantly influenced by the presence of a carbodimide stabilizer in the agent. There is no reason to expect any deviation from a direct correlation between total soman concentration and toxicity.
有关梭曼（频那基甲基膦酰氟）在水溶液中特性的信息匮乏，限制了其作为毒理学或药理学试剂的应用。我们在此报告梭曼在实验室使用和储存过程中通常会遇到的条件下的稳定性。1 mM梭曼的生理盐水溶液在-90℃储存5个月后未水解。反复解冻但未升温至室温然后立即重新冷冻的样品未显示明显水解。同一溶液的部分样品，储存在略高于冰点的冰箱中，150天后水解50%。当该溶液的部分样品储存在21℃时，50%水解的时间超过5天。所有四种梭曼立体异构体的水解速率相同。在pH值为7.4、8.0和8.6的缓冲溶液中，27℃时的半衰期分别为6.6、3.2和2.2小时，37℃时分别为4.8、1.6和1.2小时。试剂中碳二亚胺稳定剂的存在对水解速率没有显著影响。没有理由预期总梭曼浓度与毒性之间的直接相关性会有任何偏差。
