Pawełczyk E, Knitter B
Pharmazie. 1978 Sep;33(9):586-8.
A method was worked out which allows one to obtain 3% aqueous indometacin solution. The above can be done by solubilization of indometacin by means of ethyl carbamate and ethylurea in the concentration of 30% each and boiling the mixture for 30 s. The stability of indometacin in the above solution was checked with respect to elevated temperatures and exaggerated UV light conditions and compared with the stability of the same solution but without the solubilizing agents. It appears that the solubilizing agents diminish both the hydrolytic as well as the photochemical degradation processes of indometacin. 3% aqueous indometacin solution is stable for 25 months at 20 degrees C, and it is practically non-susceptible to the effects of diffused light for many years. The indometacin solution proposed shows low acidity (pH = 6.95). It is believed that the above solution can be introduced to everyday medical treatment.
已研发出一种可制备3%吲哚美辛水溶液的方法。上述操作可通过用氨基甲酸乙酯和脲以各30%的浓度溶解吲哚美辛，并将混合物煮沸30秒来实现。针对高温和强紫外线条件，对上述溶液中吲哚美辛的稳定性进行了检测，并与不含增溶剂的相同溶液的稳定性进行了比较。结果显示，增溶剂可减少吲哚美辛的水解和光化学降解过程。3%吲哚美辛水溶液在20℃下可稳定保存25个月，并且多年来实际上不易受到散射光的影响。所提出的吲哚美辛溶液酸度较低（pH = 6.95）。据信上述溶液可用于日常医学治疗。
