Okore V C
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
Boll Chim Farm. 1997 Dec;136(11):680-4.
The effect of sodium acetate on the aqueous solubility of indomethacin was studied. Increases in solubility were associated with the presence of sodium acetate in the dissolution medium. The mechanism of solubilisation was considered in relation to the possible effects of highly water-soluble substances on the structure of water. Thermodynamic conditions associated with the interactions were found to be favourable to the proposed mechanism. However, indomethacin was hydrolytically unstable in the solubilised state.
研究了醋酸钠对吲哚美辛水溶性的影响。溶解度的增加与溶解介质中醋酸钠的存在有关。结合高水溶性物质对水结构的可能影响，对增溶机制进行了探讨。发现与相互作用相关的热力学条件有利于所提出的机制。然而，吲哚美辛在增溶状态下易水解不稳定。
