Bailey D N
J Anal Toxicol. 1981 Nov-Dec;5(6):279-82. doi: 10.1093/jat/5.6.279.
Sixty cases of methaqualone ingestion have been reviewed from 1977 through 1980. Serum methaqualone concentrations, clinical information, and demographic data were studied in order to define the present status of abuse of this drug. The average user was a 27 year-old man who ingested Quaalude plus at least one additional drug (usually a narcotic analgesic, ethanol, a benzodiazepine, or a barbiturate, in that order). He was admitted to the emergency room with a depressed level of consciousness and a serum methaqualone concentration of 5 +/- 3 mg/L (mean +/- SD). Following a brief period of observation and supportive care, he was discharged from the hospital. Serum methaqualone concentrations showed no significant correlation with the physical findings, except that levels greater than or equal to 9 mg/L were always associated with a depressed level of consciousness, whether or not other drugs were present. Despite strict federal controls, methaqualone abuse appears to be a continuing problem, and analysis for this drug should be part of the toxicology screen.
回顾了1977年至1980年间60例摄入甲喹酮的病例。研究血清甲喹酮浓度、临床信息和人口统计学数据，以确定该药物的滥用现状。普通使用者为一名27岁男性，摄入了安眠酮以及至少一种其他药物（通常依次为麻醉性镇痛药、乙醇、苯二氮䓬类药物或巴比妥类药物）。他因意识水平降低和血清甲喹酮浓度为5±3mg/L（平均值±标准差）而被送入急诊室。经过短暂观察和支持治疗后，他出院了。血清甲喹酮浓度与体格检查结果无显著相关性，不过，无论是否存在其他药物，浓度大于或等于9mg/L时总是与意识水平降低相关。尽管有严格的联邦管控措施，但甲喹酮滥用似乎仍是一个持续存在的问题，对该药物的分析应作为毒理学筛查的一部分。
