Owen R T
Methods Find Exp Clin Pharmacol. 1980 Apr;2(3):133-7.
Bilateral intrastriatal injection of kainic acid in conscious guinea-pigs induced a spectrum of behaviours comprising: biting, seizures and hyperactivity. Preliminary findings revealed that pharmacological modification of these behaviours was possible. Metoclopramide, haloperidol, reserpine, flurazepam, quipazine, propranolol and aceperone were found to be inactive or very weakly active on the biting behaviours and seizures. Intrastriatal GABA decreased seizure activity but not the biting, whilst RS86, clonazepam, oxiperomide and tiapride decreased biting and seizures. It is suggested that intrastriatal kainate-induced behaviour may be a useful model for delineating agents with antidyskinetic or antichoreic potential. However, the spectrum of behaviour is not always consistent and the mortality rate is high over the subsequent 24 hours.
在清醒的豚鼠双侧纹状体内注射海藻酸会诱发一系列行为，包括：咬、癫痫发作和多动。初步研究结果表明，对这些行为进行药理学修饰是可能的。发现甲氧氯普胺、氟哌啶醇、利血平、氟西泮、喹哌嗪、普萘洛尔和阿塞哌隆对咬行为和癫痫发作无活性或活性非常弱。纹状体内注射GABA可降低癫痫发作活性，但对咬行为无效，而RS86、氯硝西泮、奥昔哌隆和硫必利可减少咬行为和癫痫发作。有人认为，纹状体内注射海藻酸盐诱导的行为可能是一种有用的模型，用于筛选具有抗运动障碍或抗舞蹈病潜力的药物。然而，行为谱并不总是一致的，并且在随后的24小时内死亡率很高。
