Robertson C E
Methods Find Exp Clin Pharmacol. 1980 Aug;2(4):167-9.
Single doses of 750 mg of cefuroxime lysine were given to eight elderly patients. The mean plasma half life was 124 minutes and the mean time to peak was 82 minutes. When compared with previous studies in young healthy volunteers, while peak plasma concentrations are similar, there is prolongation of half life and delay of excretion of the drug in the elderly. In our group studied, no local discomfort was noted following injection.
给8名老年患者单次静脉注射750mg赖氨匹林。平均血浆半衰期为124分钟，平均达峰时间为82分钟。与之前在年轻健康志愿者中的研究相比，老年患者的血浆峰浓度相似，但半衰期延长，药物排泄延迟。在我们的研究组中，注射后未观察到局部不适。
