Shah P M
Methods Find Exp Clin Pharmacol. 1980 Aug;2(4):171-6.
The bacterial activity of cefoxitin was studied in an improved in vitro model simulating serum levels. The peak concentration of cefoxitin was 110 mcg/ml as achieved after 1 g i.v. Half-life time was adjusted to 50 minutes. The time at which the viable count reached the mark 1% of the original inoculum after the lowest count was determined (regrowth period) ranged from one to 10 hours from the beginning of the experiments.
在一个模拟血清水平的改进体外模型中研究了头孢西丁的细菌活性。静脉注射1g后，头孢西丁的峰值浓度达到110μg/ml。半衰期调整为50分钟。从实验开始起，确定活菌数在最低计数后达到原始接种量1%的时间（再生长阶段）为1至10小时。
