体外动态模型中抗菌作用动力学的定量分析。
Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model.
作者信息
Firsov A A, Chernykh V M, Navashin S M
机构信息
Department of Pharmacokinetics, National Research Institute of Antibiotics, Moscow, USSR.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1312-7. doi: 10.1128/AAC.34.7.1312.
Abstract
Variants of the available methods for estimating antimicrobial effect kinetics in an in vitro dynamic model were analyzed. Two integral parameters characterizing antimicrobial effect duration (TE) and intensity (IE) are suggested to define and analyze the concentration-effect relationships in these models, irrespective of the method of recording. TE is defined by the time from the moment of antibiotic administration to the movement when the bacterial count again reaches its initial level. IE is defined by the area between the microbial growth curves in the presence and absence of an antibiotic. TE and IE were used to quantify the antimicrobial effects of sisomicin on Pseudomonas aeruginosa 58, Escherichia coli 93, and Klebsiella pneumoniae 5056, simulating the pharmacokinetic profiles of the drugs observed following intramuscular administration in therapeutic doses, including the variability of aminoglycoside concentrations in human blood.
摘要
分析了体外动态模型中估计抗菌作用动力学的现有方法的变体。建议使用两个表征抗菌作用持续时间（TE）和强度（IE）的积分参数来定义和分析这些模型中的浓度-效应关系，而不管记录方法如何。TE定义为从给予抗生素的时刻到细菌数量再次达到其初始水平时的移动时间。IE定义为存在和不存在抗生素时微生物生长曲线之间的面积。使用TE和IE来量化西索米星对铜绿假单胞菌58、大肠杆菌93和肺炎克雷伯菌5056的抗菌作用，模拟治疗剂量肌内给药后观察到的药物药代动力学特征，包括人血中氨基糖苷类浓度的变异性。
相似文献
1
Quantitative analysis of antimicrobial effect kinetics in an in vitro dynamic model.体外动态模型中抗菌作用动力学的定量分析。
Antimicrob Agents Chemother. 1990 Jul;34(7):1312-7. doi: 10.1128/AAC.34.7.1312.
2
[Principles for analyzing the kinetic curves of the antimicrobial effect in dynamic systems simulating the pharmacokinetic profiles of antibiotics].
Antibiot Med Biotekhnol. 1987 Feb;32(2):122-9.
3
A dynamic model for in-vitro evaluation of antimicrobial action by simulation of the pharmacokinetic profiles of antibiotics.
J Antimicrob Chemother. 1989 Mar;23(3):389-99. doi: 10.1093/jac/23.3.389.
4
[Kinetics of the antimicrobial effect in a dynamic system: the microcalorimetric recording method and choice of parameters for characterizing kinetic curves].
Antibiot Med Biotekhnol. 1985 Jul;30(7):498-503.
5
6
Pharmacodynamics of plazomicin and a comparator aminoglycoside, amikacin, studied in an in vitro pharmacokinetic model of infection.在感染的体外药代动力学模型中研究了帕拉米星和比较氨基糖苷类药物阿米卡星的药效动力学。
Int J Antimicrob Agents. 2019 Nov;54(5):626-632. doi: 10.1016/j.ijantimicag.2019.07.001. Epub 2019 Jul 9.
7
In vitro bacteriological study of a new antibiotic substance: sisomicin.一种新型抗生素物质：西索米星的体外细菌学研究
Zentralbl Bakteriol Orig A. 1975 Jan;230(1):104-11.
8
In vitro studies with sisomicin and gentamicin.西索米星与庆大霉素的体外研究。
Chemotherapy. 1976;22(6):346-52. doi: 10.1159/000221946.
9
In vitro simulated pharmacokinetics profiles: forecasting antibiotic optimal dosage.
Eur J Drug Metab Pharmacokinet. 1991;Spec No 3:406-9.
10
Gentamicin, tobramycin, and sisomicin disc susceptibility tests. Revised zone standards for interpretation.庆大霉素、妥布霉素和西索米星纸片药敏试验。修订后的抑菌圈解释标准。
Am J Clin Pathol. 1981 Apr;75(4):524-31. doi: 10.1093/ajcp/75.4.524.
引用本文的文献
1
Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure-Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant .新型药代动力学/药效学参数量化了左氧氟沙星对氟喹诺酮耐药菌的暴露-效应关系。
Antibiotics (Basel). 2021 May 21;10(6):615. doi: 10.3390/antibiotics10060615.
2
Pharmacodynamic and response surface analysis of linezolid or vancomycin combined with meropenem against Staphylococcus aureus.利奈唑胺或万古霉素联合美罗培南对金黄色葡萄球菌的药效学及响应面分析
Pharm Res. 2015 Jul;32(7):2410-8. doi: 10.1007/s11095-015-1632-3. Epub 2015 Jan 30.
3
Bacterial resistance studies using in vitro dynamic models: the predictive power of the mutant prevention and minimum inhibitory antibiotic concentrations.使用体外动态模型进行细菌耐药性研究：突变预防浓度和最低抑菌抗生素浓度的预测能力。
Antimicrob Agents Chemother. 2013 Oct;57(10):4956-62. doi: 10.1128/AAC.00578-13. Epub 2013 Jul 29.
4
Comparative pharmacodynamics and antimutant potentials of doripenem and imipenem with ciprofloxacin-resistant Pseudomonas aeruginosa in an in vitro model.比较体外模型中多利培南和亚胺培南与环丙沙星耐药铜绿假单胞菌的比较药效学和抗突变潜力。
Antimicrob Agents Chemother. 2012 Mar;56(3):1223-8. doi: 10.1128/AAC.05964-11. Epub 2011 Dec 27.
5
Antibiotic pharmacodynamics and bacterial resistance: usefulness of in vitro models.抗生素药效学与细菌耐药性：体外模型的实用性
Curr Infect Dis Rep. 2007 May;9(3):175-7. doi: 10.1007/s11908-007-0027-y.
6
Antistaphylococcal effect related to the area under the curve/MIC ratio in an in vitro dynamic model: predicted breakpoints versus clinically achievable values for seven fluoroquinolones.体外动态模型中与曲线下面积/MIC比值相关的抗葡萄球菌效应：七种氟喹诺酮类药物的预测断点与临床可达到值
Antimicrob Agents Chemother. 2005 Jul;49(7):2642-7. doi: 10.1128/AAC.49.7.2642-2647.2005.
7
Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.抗感染药物的药代动力学和药效学问题：杀菌曲线与最低抑菌浓度
Antimicrob Agents Chemother. 2004 Feb;48(2):369-77. doi: 10.1128/AAC.48.2.369-377.2004.
8
In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus.使用四种氟喹诺酮类药物对金黄色葡萄球菌进行突变选择窗假说的体外药效学评价。
Antimicrob Agents Chemother. 2003 May;47(5):1604-13. doi: 10.1128/AAC.47.5.1604-1613.2003.
9
Relationships of the area under the curve/MIC ratio to different integral endpoints of the antimicrobial effect: gemifloxacin pharmacodynamics in an in vitro dynamic model.曲线下面积与最低抑菌浓度比值与抗菌效应不同积分终点的关系：体外动态模型中的吉米沙星药效学
Antimicrob Agents Chemother. 2001 Mar;45(3):927-31. doi: 10.1128/AAC.45.3.927-931.2001.
10
Use of Modeling Techniques to Aid in Antibiotic Selection.使用建模技术辅助抗生素选择。
Curr Infect Dis Rep. 2001 Feb;3(1):35-43. doi: 10.1007/s11908-001-0057-9.
本文引用的文献
1
An improved method to study antibacterial activity of antibiotics in an in vitro model simulating serum levels.一种在模拟血清水平的体外模型中研究抗生素抗菌活性的改进方法。
Methods Find Exp Clin Pharmacol. 1980 Aug;2(4):171-6.
2
Antibacterial effects of cefroxadine, cephalexin and cephradine in a new in vitro pharmacokinetic model.头孢沙定、头孢氨苄和头孢拉定在新型体外药代动力学模型中的抗菌作用
J Antibiot (Tokyo). 1982 Jul;35(7):843-9. doi: 10.7164/antibiotics.35.843.
3
A test and calibration process for microcalorimeters used as thermal power meters.用作热功率计的微热量计的测试与校准过程。
J Biochem Biophys Methods. 1982 Sep;6(4):297-306. doi: 10.1016/0165-022x(82)90011-2.
4
New in vitro kinetic model for evaluating bactericidal efficacy of antibiotics.用于评估抗生素杀菌效果的新型体外动力学模型。
Antimicrob Agents Chemother. 1980 Sep;18(3):377-81. doi: 10.1128/AAC.18.3.377.
5
6
In-vitro activity of cefotetan, other beta-lactams and netilmicin.
J Antimicrob Chemother. 1983 Jan;11 Suppl:73-8. doi: 10.1093/jac/11.suppl_a.73.
7
The activity of cefotiam on beta-lactamase-producing bacteria in an in-vitro model.头孢替安在体外模型中对产β-内酰胺酶细菌的活性。
J Antimicrob Chemother. 1984 Feb;13(2):111-9. doi: 10.1093/jac/13.2.111.
8
Antibacterial activity of aminosidine and of beta-lactamic antibiotics.氨基糖苷类药物和β-内酰胺类抗生素的抗菌活性。
Farmaco Prat. 1974 Jan;29(1):21-6.
9
Influence of ampicillin elimination half-life on in-vitro bactericidal effect.氨苄西林消除半衰期对体外杀菌效果的影响。
J Antimicrob Chemother. 1985 Jan;15 Suppl A:257-60. doi: 10.1093/jac/15.suppl_a.257.
10
Impact of netilmicin regimens on the activities of ceftazidime-netilmicin combinations against Pseudomonas aeruginosa in an in vitro pharmacokinetic model.在体外药代动力学模型中奈替米星给药方案对头孢他啶-奈替米星联合用药抗铜绿假单胞菌活性的影响。
Antimicrob Agents Chemother. 1985 Jul;28(1):64-8. doi: 10.1128/AAC.28.1.64.
Zotero 插件