McGinness J E, Proctor P H, Demopoulos H B, Hokanson J A, Kirkpatrick D S
Physiol Chem Phys. 1978;10(3):267-77.
In rats, daily administration of subcutaneous dose of 2.5 mg/kg of orgotein, the pharmaceutical preparation of Zn-Cu superoxide dismutase, lowers the nephrotoxicity induced by a 5.0 mg/kg dose of the antitumor agent cis-platinum (cis-diaminedichloroplatinum II). The toxicity of cis-platinum was studied by comparative measurements of blood urea nitrogen and changes in body weight, and by comparative renal histology. In addition to their direct clinical applicability, these results support a role for pathologic levels of oxygen radicals in the etiology of the nephrotoxicity of cis-platinum.
在大鼠中，每日皮下注射剂量为2.5毫克/千克的奥古蛋白（一种锌 - 铜超氧化物歧化酶的药物制剂），可降低由5.0毫克/千克剂量的抗肿瘤药物顺铂（顺 - 二氨二氯铂II）诱导的肾毒性。通过比较测量血尿素氮和体重变化以及比较肾脏组织学来研究顺铂的毒性。除了其直接的临床适用性外，这些结果支持了氧自由基的病理水平在顺铂肾毒性病因学中的作用。
