Kandarkar S V, Hasgekar N N, Sirsat S M
Neoplasma. 1981;28(6):729-37.
A close correlation is postulated between tobacco chewing and the high incidence of oral cancer and precancer in many South East Asian nations. However, attempts to induce malignancy in laboratory animals by exposure to ingredients of betel quid are unsuccessful. This is another attempt to induce malignancy in the hamster cheek pouch epithelium by exposure to the ingredients of betel quid - lime and tobacco, for the total life span of the animals - 100 to 110 weeks. Parallel conditioning by exposure to vitamin A is also included. The cheek pouch epithelium of animals exposed to the test substances for total life span shows only epithelial dysplasia of a marked degree, but no evidence of malignancy. It is concluded that it is not possible to simulate the time-dose relationship in human addiction to tobacco or to betel chew in experimental animals due to their comparatively small life span.
在许多东南亚国家，人们推测嚼烟草与口腔癌及癌前病变的高发病率之间存在密切关联。然而，通过让实验动物接触槟榔成分来诱发恶性肿瘤的尝试并未成功。这是又一次尝试，在动物的整个生命周期（100至110周）内，通过让仓鼠颊囊上皮接触槟榔成分（石灰和烟草）来诱发恶性肿瘤。同时还包括通过接触维生素A进行平行对照。在整个生命周期内接触受试物质的动物的颊囊上皮仅表现出明显程度的上皮发育异常，但没有恶性肿瘤的迹象。得出的结论是，由于实验动物的寿命相对较短，因此不可能在实验动物中模拟人类对烟草或槟榔咀嚼成瘾的时间-剂量关系。
