Davidson P T, Khanijo V, Goble M, Moulding T S
Rev Infect Dis. 1981 Sep-Oct;3(5):1052-9. doi: 10.1093/clinids/3.5.1052.
During eleven and one-half years, 122 patients with M. intracellulare disease were treated at National Jewish Hospital and Research Center, Denver, Colorado. Of the 81 patients treated with multiple drug chemotherapy, 63 (78%) were considered to be treatment successes. On follow-up (averaging 55 months) 40 of the 63 patients had remained clinically stable or improved and 12 had grown worse. Ten of these 63 patients had relapsed. Of the 63 patients considered to be treatment successes, 23 (36.5%) had died during follow-up, mostly of pulmonary disease. Of the 18 patients who failed to respond to chemotherapy, 2 were later successfully treated with surgery, 5 patients were clinically worsening, and 8 (44%) had died during a follow-up period averaging 43 months. A group of 41 patients had indeterminate results with chemotherapy. Eight had died while in the hospital. Follow-up information after an average of 43 months indicated that 9 patients became treatment successes (5 with chemotherapy, 4 with surgery), 12 were clinically stable or improving, and an additional 13 had died for a total of 21 deaths (51%). The overall success of treatment in the 122 patients was 61%. Fifty-two (43%) died during the study. Many patients will respond to drug therapy and remain clinically well for years. Because of the potential seriousness of this disease in some patients, multiple drug chemotherapy should be used.
在11年半的时间里，科罗拉多州丹佛市的国家犹太医院和研究中心对122例细胞内分枝杆菌病患者进行了治疗。在接受多药化疗的81例患者中，63例（78%）被认为治疗成功。随访（平均55个月）发现，63例患者中有40例临床症状保持稳定或有所改善，12例病情恶化。这63例患者中有10例复发。在被认为治疗成功的63例患者中，23例（36.5%）在随访期间死亡，主要死于肺部疾病。在18例化疗无反应的患者中，2例后来通过手术成功治疗，5例临床症状恶化，8例（44%）在平均43个月的随访期内死亡。41例患者化疗结果不确定。其中8例在住院期间死亡。平均43个月的随访信息显示，9例患者治疗成功（5例通过化疗，4例通过手术），12例临床症状稳定或有所改善，另有13例死亡，共计21例死亡（51%）。122例患者的总体治疗成功率为61%。52例（43%）在研究期间死亡。许多患者对药物治疗有反应，并能临床康复多年。由于这种疾病在一些患者中可能很严重，应采用多药化疗。
