Wanner A
Z Erkr Atmungsorgane. 1981;157(3):252-5.
The presence of mucociliary dysfunction in bronchial asthma is suggested by clinical observations and has been confirmed by pathologic and physiologic studies. Since mucociliary dysfunction may play a considerable role in the pathophysiology of bronchial asthma, currently available therapeutic measures which enhance mucous transport should be included in the treatment plan. It is expected that a better understanding of the underlying mechanisms will ultimately result in the development of more potent pharmacologic agents capable of improving abnormal mucociliary function.
临床观察提示支气管哮喘存在黏液纤毛功能障碍，病理和生理学研究已证实这一点。由于黏液纤毛功能障碍可能在支气管哮喘的病理生理学中起相当大的作用，目前可用的增强黏液转运的治疗措施应纳入治疗方案。预计对潜在机制的更好理解最终将导致开发出更有效的能够改善异常黏液纤毛功能的药物。
