Wanner A
Am J Med. 1979 Sep;67(3):477-85. doi: 10.1016/0002-9343(79)90797-6.
Abnormalities of mucociliary function in the airways of patients with bronchial asthma are suggested by the clinical observation of excessive tracheobronchial secretions which are difficult to expectorate and may contribute to bronchial obstruction. Pathologic and functional studies in animals and patients have demonstrated an impairment of mucociliary transport mechanisms, but the pathogenesis of this abnormality is still poorly understood. In patients with allergic asthma, the elaboration of chemical mediators in the lung seems to depress mucociliary function. Although pharmacologic agents which increase mucous transport rates have been identified, more potent stimulators will probably be needed to produce a clinical improvement in patients with bronchial asthma.
支气管哮喘患者气道中黏液纤毛功能异常，这一点可从临床观察中得到提示，即气管支气管分泌物过多，难以咳出，且可能导致支气管阻塞。对动物和患者的病理及功能研究表明，黏液纤毛转运机制受损，但这种异常的发病机制仍知之甚少。在过敏性哮喘患者中，肺部化学介质的释放似乎会抑制黏液纤毛功能。虽然已经确定了能提高黏液转运速率的药物，但可能需要更有效的刺激剂才能使支气管哮喘患者的病情得到临床改善。
